Which USP chapters are most relevant to sterile compounding and to handling hazardous drugs in pharmacy?

• A. USP <797> and USP <800>
• B. USP <795> and USP <797>
• C. USP <800> and USP <825>
• D. USP <1000> and USP <1058>

Answer: (A)

The main idea being tested is which USP chapters cover both preparing sterile products and safely handling drugs that are hazardous to staff. For sterile compounding, a chapter lays out the requirements for aseptic technique, cleanroom design, garbing, environmental monitoring, sterilization and sterility assurance, and quality controls that prevent contamination of injections and other sterile products. For hazardous drugs, another chapter provides the practices to protect both the healthcare workers and the environment—engineering controls like biosafety cabinets, appropriate personal protective equipment, training, storage, labeling, handling during compounding, administration, and waste or spill management. Together, these two chapters address how to prepare sterile medicines while keeping staff safe when handling drugs with potential cytotoxic or harmful effects.

Other options don’t fit as well because they either emphasize non-sterile compounding, or focus on radiopharmaceuticals or general quality topics that don’t specifically cover both sterile compounding and hazardous drug handling.